Ideal for readers encountering biochemistry for the first time, Garrett and Grisham's BIOCHEMISTRY, Seventh Edition, makes even complex course concepts more accessible while revealing the beauty and usefulness of biochemistry in the everyday world. This engaging text illuminates the fundamental principles governing the structure, function and interactions of biological molecules, providing a solid foundation in biochemistry whether you are an undergraduate majoring in life sciences, chemistry or premedical programs, or a medical or graduate health sciences student seeking a deeper understanding of human physiology. Updated to reflect tremendous recent developments in biochemistry, the Seventh Edition features new and revised material and presentations throughout the text, incorporating additional content while maintaining a balanced and streamlined presentation. In addition, the authors emphasize the interrelationships of ideas to help you appreciate the overarching questions of biochemistry. The text is also integrated with OWLv2, a powerful online learning system for chemistry with text-specific end-of-chapter material to help you improve your grades and master course concepts.

Table of Contents

Part I: Molecular Components of Cells

Chapter 1: The Facts of Life: Chemistry Is the Logic of Biological Phenomena

Chapter 2: Water: The Medium of Life

Chapter 3: Thermodynamics of Biological Systems

Chapter 4: Amino Acids and the Peptide Bond

Chapter 5: Proteins: Their Primary Structure and Biological Functions

Chapter 6: Proteins: Secondary, Tertiary, and Quaternary Structure

Chapter 7: Carbohydrates and the Glycoconjugates of Cell Surfaces

Chapter 8: Lipids

Chapter 9: Membranes and Membrane Transport

Chapter 10: Nucleotides and Nucleic Acids

Chapter 11: Structure of Nucleic Acids

Chapter 12: Recombinant DNA, Cloning, Gene Editing, and Synthetic Biology - An Introduction

Part II: Protein Dynamics

Chapter 13: Enzymes - Kinetics and Specificity

Chapter 14: Mechanisms of Enzyme Action

Chapter 15: Enzyme Regulation

Chapter 16: Molecular Motors

Part III: Metabolism and Its Regulation

Chapter 17: Metabolism: An Overview

Chapter 18: Glycolysis

Chapter 19: The Tricarboxylic Acid Cycle

Chapter 20: Electron Transport and Oxidative Phosphorylation

Chapter 21: Photosynthesis

Chapter 22: Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate Pathway

Chapter 23: Fatty Acid Catabolism

Chapter 24: Lipid Biosynthesis

Chapter 25: Nitrogen Acquisition and Amino Acid Metabolism

Chapter 26: Synthesis and Degradation of Nucleotides

Chapter 27: Metabolic Integration and Organ Specialization

Part IV: Information Transfer

Chapter 28: DNA Metabolism: Replication, Recombination, and Repair

Chapter 29: Transcription and the Regulation of Gene Expression

Chapter 30: Protein Synthesis

Chapter 31: Completing the Protein Life Cycle: Folding, Processing, and Degradation

Chapter 32: The Reception and Transmission of Extracellular Information

About the Author

Reginald H. Garrett was educated in the Baltimore city public schools and at the Johns Hopkins University, where he received his Ph.D. in biology in 1968. Since that time, he has conducted research and taught biochemistry courses at the University of Virginia, where he is currently Professor of Biology. He is the author of numerous papers and review articles on biochemical, genetic, and molecular biological aspects of inorganic nitrogen metabolism. His early research focused on the pathway of nitrate assimilation in filamentous fungi. His investigations contributed substantially to our understanding of the enzymology, genetics, and regulation of this major pathway of biological nitrogen acquisition. More recently, he has collaborated in systems approaches to the metabolic basis of nutrition-related diseases. His research has been supported by grants from the National Institutes of Health, the National Science Foundation, and private industry. A member of the American Society for Biochemistry and Molecular Biology, Garrett is a former Fulbright Scholar, was twice Visiting Scholar at the University of Cambridge, and was Invited Professor at the University of Toulouse, France.

Charles M. Grisham received his B.S. in chemistry from the Illinois Institute of Technology in 1969 and his Ph.D. in chemistry from the University of Minnesota in 1973. Following a postdoctoral appointment at the Institute for Cancer Research in Philadelphia, he became Professor of Chemistry at the University of Virginia, where he teaches biochemistry, introductory chemistry, and physical chemistry. He has authored numerous papers and review articles on active transport of sodium, potassium, and calcium in mammalian systems, on protein kinase C, and on the applications of NMR and EPR spectroscopy to the study of biological systems. His work has been supported by the National Institutes of Health, the National Science Foundation, the Muscular Dystrophy Association of America, the Research Corporation, the American Heart Association and the American Chemical Society. A member of the American Society for Biochemistry and Molecular Biology, Grisham held the Knapp Chair in Chemistry in 1999 at the University of San Diego; was Visiting Scientist at the Aarhus University Institute of Physiology, Aarhus, Denmark, for two years; and received a Research Career Development Award from the National Institutes of Health.